Cell geometries extracted with MorphoGraphX can be exported and used as templates for simulation models, providing a powerful platform to investigate the interactions between shape, genes and growth.Īnimals, plants and other multicellular organisms develop their distinctive three-dimensional shapes as they grow. The software's modular design makes it easy to include existing libraries, or to implement new algorithms. In addition to traditional 3D image analysis, we have developed algorithms to operate on curved surfaces, such as cell segmentation, lineage tracking and fluorescence signal quantification. Here we present MorphoGraphX ( a software that bridges this gap by working directly with curved surface images extracted from 3D data. This quantification is usually performed either in full 3D, which is computationally expensive and technically challenging, or on 2D planar projections, which introduces geometrical artifacts on highly curved organs. To understand these processes, the evolution of cell shape, proliferation and gene expression must be quantified. Morphogenesis emerges from complex multiscale interactions between genetic and mechanical processes.
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